Tetrabutylammonium Fluoride → HCID 58822601, compound

Participants

Reaction Steps

(1R*,3S*)-[3-(Biphenyl-4-yloxy)-cyclopentyloxy]-tert-butyldimethylsilane (0.25 g, 0.67 mmol) was dissolved in 2 mL of THF and tetrabutylammonium fluoride (0.67 mL, 1M in THF) and stirred at room temperature for 2 hours. The solution was diluted with 15 mL of diethyl ether and washed with 1N HCl (2×15 mL). The organic layer was dried (MgSO4) and concentrated. The residue was purified by silica gel chromatography (silica gel, hexanes/ethyl acetate 3:1, Rf0.09) to give the product (100%). 1H-NMR (200.15 MHz, CDCl3): δ 7.58–7.26 (m, 7H), 6.95 (d, 2H, J=8.9), 4.92–4.84 (m, 1H), 4.40–4.38 (m, 1H), 2.18–1.92 (m, 7H).

Provenance & Evidence