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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459126Generated: October 25, 2026

2,4-Difluorophenol → (2S)-3-{4-[3-(2,4-Difluoro-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid

https://huagongshe.com/reaction/459126

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DifluorophenolHCID 123051—
Reactant(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acidHCID 69424952—
Product(2S)-3-{4-[3-(2,4-Difluoro-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acidHCID 58822895—

Reaction Steps

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 2,4-difluorophenol and cleavage from the resin (Standard Procedure G) gave an oily solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192982B2
Source datasetuspto-grants-2007_03
ORD IDord-9f7877dbb1384dddbcfa216bc8b89fb3
Source noteuspto-grants-2007_03