HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenol → (2S)-2-Methoxy-3-{4-[3-(4-trifluoromethyl-phenoxy)-propoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| Reactant | (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid | HCID 69424952 | — |
| Product | (2S)-2-Methoxy-3-{4-[3-(4-trifluoromethyl-phenoxy)-propoxy]-phenyl}-propionic acid | HCID 58822642 | — |
Reaction Steps
The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 4-trifluoromethylphenol and cleavage from the resin (Standard Procedure G) gave an oily solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-60b40dc07df24afca246c42268b74f2a |
| Source note | uspto-grants-2007_03 |