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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459128Generated: October 26, 2026

3-(Trifluoromethyl)phenol → (2S)-2-Methoxy-3-{4-[3-(3-trifluoromethyl-phenoxy)-propoxy]-phenyl}-propionic acid

https://huagongshe.com/reaction/459128

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)phenolHCID 7376—
Reactant(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acidHCID 69424952—
Product(2S)-2-Methoxy-3-{4-[3-(3-trifluoromethyl-phenoxy)-propoxy]-phenyl}-propionic acidHCID 58822762—

Reaction Steps

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin Example 94, Step D) via Mitsunobu coupling with 3-trifluoromethylphenol and cleavage from the resin (Standard Procedure CG) gave an oily solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192982B2
Source datasetuspto-grants-2007_03
ORD IDord-c6d51a23c7024a20b20baae1aa8f441a
Source noteuspto-grants-2007_03