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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459137Generated: October 25, 2026

6-Hydroxyflavanone → (2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-chroman-6-yloxy)-propoxy]-phenyl}-propionic acid

https://huagongshe.com/reaction/459137

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-HydroxyflavanoneHCID 2734580—
Reactant(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acidHCID 69424952—
Product(2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-chroman-6-yloxy)-propoxy]-phenyl}-propionic acidHCID 58822982—

Reaction Steps

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 6-hydroxyflavanone and cleavage from the resin (Standard Procedure G) gave an oily solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192982B2
Source datasetuspto-grants-2007_03
ORD IDord-906f3a7a607c451ca81fa73719fc450c
Source noteuspto-grants-2007_03