2-(tert-Butyl(dimethyl)silyl)oxyethanol → HCID 69423300, compound

HRID 459138Notes

Reaction equation

HRID 459138 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@H:9]([O:13][CH3:14])[C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[Si:15]([O:22][CH2:23][CH2:24]O)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]>>[C:18]([Si:15]([CH3:17])([CH3:16])[O:22][CH2:23][CH2:24][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C@H:9]([O:13][CH3:14])[C:10]([OH:12])=[O:11])=[CH:6][CH:7]=1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 111376652-(tert-Butyl(dimethyl)silyl)oxyethanolHCID 11564639(2S)-3-(4-hydroxyphenyl)-2-methoxypropanoic acid

Product 1

HCID 69423300HCID 69423300, compound

Procedure

The title compound was prepared from (2S)-3-(4-hydroxy-phenyl)-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via the Mitsunobu coupling procedure with 2-(tert-butyldimethylsilanyloxy)ethanol (Standard Procedure B).

Sources & evidence

ORD record
ord-941a4e3bb9044012a0d88c7109145163
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

Loading…