Formic Acid → HCID 72436296, compound

Participants

Reaction Conditions

Reaction Steps

To (2S)-3-(4-Ethynyl-phenyl)-2-methoxy-propionic acid ethyl ester (36 Mg, 0.15 mmol) (Example 29, Step A) were added 4 ml of formic acid. The solution was stirred for 1 hour at 100° C. and then cooled to room temperature. The mixture was taken up with methylene chloride and the solution was washed with water, sodium carbonate, and water, dried (MgSO4) and the solvent was evaporated under vacuum. Obtained a brown liquid (0.035 g, 95%). 1H-NMR (200.15 MHz, CDCl3): δ 7.43 (d, 1H, J=73), 7.12 (d, 1H, J=7.3), 4.18 (q, 2H, J=7.0), 3.97 (dd, 1H, J=7.3, 5.6), 3.32 (s, 3H), 3.06 (s, 1H), 3.03 (d, 1H, J=2.4 Hz), 2.56 (s, 2H), 1.22 (t, 3H, J=7.25).

Provenance & Evidence