HCID 18443225, compound → HCID 58822718, compound

Participants

Reaction Steps

The title compound was prepared as follows: (2S) 3-{4-[3-(Biphenyl-4-yloxy)-prop-1-ynyl]-phenyl}-2-methoxy-propionic acid (0, Step C) (0.0325 g, 0.08 mmol) was dissolved in methanol (10 mL). Palladium 10% an activated carbon (0.004 g, 0.004 mmol) was added and the solution saturated with hydrogen (1 Atm) and stirred for 5 hours. The mixture was filtered through a pad of celite and concentrated under vacuum. The residue was purified by column chromatography (silica gel, hexanes/Ethyl acetate-Acetic acid 50:50:1, Rf0.23) (85%). 1H-NMR (CDCl3, 200.15 MHz): δ 7.56–7.24 (m, 11H), 6.94 (d, 2H, J=8.8), 4.02–3.95 (m, 3H), 3.38 (s, 3H), 3.11 (dd, 1H, J=14.3, 4.4), 2.98 (dd, 1H, J=14.3, 7.3), 2.79 (t, 2H, J=8.1), 2.16–2.03 (m, 3H). MS (ES) for C25H26O4 [M+NH4]+: 408.2, [M+Na]+: 413.2.

Provenance & Evidence