4-Hydroxybiphenyl → HCID 58822690, compound

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Reaction Steps

The title compound was prepared from (2S)-3-[4-(4-Hydroxy-butyl)-phenyl]-2-methoxy-propionic acid ethyl ester and 4-phenylphenol following the Standard Procedure of coupling-hydrolysis A. 1H-NMR (CDCl3, 200.15 MHz): δ 7.55–7.23 (m, 7H); 7.14 (d, 4H, J=1.1); 6.93 (d, 2H, J=8.4); 4.02–3.96 (m, 3H); 3.37 (s, 3H); 3.11 (dd, 1H, J=14.3, 4.4); 2.97 (dd, 1H, J=14.3, 7.3); 2.66 (t, 2H, J=7.0); 1.83–1.80 (m, 4H). MS (ES) for C26H28O4 [M+NH4]+: 422.2, [M+Na]+: 427.2.

Provenance & Evidence