HCID 18443269, compound → HCID 18443271, compound

Participants

Reaction Steps

The title compound was prepared from 2-Methoxy-3-{3-[5-(4-phenoxy-phenoxy)-pent-1-ynyl]-phenyl}-propionic acid of Example 155, Step E, and treated with Pd—C (0.1 eq) in ethyl acetate and H2. Filtered through celite and concentrated to give the compound. MS (ES) for C27H30O5 [M+H]+: 435.2, [M+NH4]+: 452.2. 1H-NMR (CDCl3, 200.15 MHz): 7.34–7.19 (m, 3H), 7.09–6.84 (m, 10H), 4.02 (dd, 1H, J=7.5, 4.6), 3.94 (t, 2H, J=6.5), 3.39 (s, 3H), 3.13 (dd, 1H, J=14.0, 4.3), 3.00 (dd, 1H, J=14.0, 7.5), 2.63 (t, 2H, J=7.8), 1.88–1.45 (m, 6H)ppm.

Provenance & Evidence