Sodium Hydroxide → 3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-3-methyl-phenyl}-2-methoxy-propionic acid

HRID 459183Notes

Reaction equation

HRID 459183 reaction equation
C([O:3][C:4](=[O:33])[C@@H:5]([O:31][CH3:32])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[C:9]([CH3:30])[CH:8]=1)C.[OH-].[Na+]>>[C:21]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:20]=[CH:19][C:18]([O:17][CH2:16][CH2:15][CH2:14][O:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:31][CH3:32])[C:4]([OH:33])=[O:3])=[CH:8][C:9]=2[CH3:30])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 58822867(2S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-3-methyl-phenyl}-2-methoxy-propionic acid ethyl ester

Product 1

HCID 184435303-{4-[3-(Biphenyl-4-yloxy)-propoxy]-3-methyl-phenyl}-2-methoxy-propionic acid

Procedure

The title compound was prepared from compound from Step F under Standard hydrolysis procedure C using NaOH.

Sources & evidence

ORD record
ord-a1d1a62ab347437baa0e7860b912e629
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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