HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-2-methoxy-phenyl}-2-methoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | [4-(3-Hydroxy-propoxy)-phenyl]-phenyl-methanone | HCID 15879680 | — |
| Reactant | 2-(4-Hydroxy-2-methoxy-benzyl)-butyric acid ethyl ester | HCID 69421263 | — |
| Reactant | HCID 178459888 | HCID 178459888 | — |
| Product | 3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-2-methoxy-phenyl}-2-methoxy-propionic acid | HCID 18443621 | — |
Reaction Steps
A mixture solution of 2-(4-Hydroxy-2-methoxy-benzyl)-butyric acid ethyl ester from Example 188, Step C and [4-(3-Hydroxy-propoxy)-phenyl]-phenyl-methanone were allowed to react under the Standard Mitsounobu coupling conditions B (DIAD/toluene) to give the corresponding coupled product which by the Standard hydrolysis procedure C (NaOH) yield the title compound. MS (ES) for C27H28O7 [M+H]+: 465.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-e123f916d1924485b78fc99aa0249660 |
| Source note | uspto-grants-2007_03 |