HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Methoxy-3-{2-methoxy-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(4-Phenoxyphenoxy)-propan-1-ol | HCID 10243540 | — |
| Reactant | 2-(4-Hydroxy-2-methoxy-benzyl)-butyric acid ethyl ester | HCID 69421263 | — |
| Reactant | HCID 178459888 | HCID 178459888 | — |
| Product | 2-Methoxy-3-{2-methoxy-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acid | HCID 10182520 | — |
Reaction Steps
A mixture solution of 2-(4-Hydroxy-2-methoxy-benzyl)-butyric acid ethyl ester from Example 188, Step C and 3-(4-phenoxy-phenoxy)-propan-1-ol were allowed to react under the Standard Mitsounobu coupling conditions B (DIAD/toluene) to give the corresponding coupled product which by the Standard hydrolysis procedure C (NaOH) yielded the title compound. MS (ES) for C26H28O7 [M+Na]+: 475.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-862fcc2562b34835ae40a05762bfbb04 |
| Source note | uspto-grants-2007_03 |