HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 18443682, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | Benzyl 4-benzyloxy-2-chlorobenzoate | HCID 22058608 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18443682 | HCID 18443682 | — |
Reaction Steps
A mixture of 4-Benzyloxy-2 chloro-benzoic acid benzyl ester from Step A with DIBAL-H 1M in toluene (2.2 eq) in THF were stirred at room temperature for 3 hours. The quenched with tartrate saturated solution and extracted with ethyl acetate. Concentrated to dryness and purified by chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-579f7e2bb277405e8be4f5a0a8c92269 |
| Source note | uspto-grants-2007_03 |