HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 18443528, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(4-Phenylphenoxy)-1-propanol | HCID 28351739 | — |
| Reactant | 3-(2-Chloro-4-hydroxy-phenyl)-2-methoxy-propionic acid ethyl ester | HCID 58823024 | — |
| Reactant | HCID 178459888 | HCID 178459888 | — |
| Product | HCID 18443528 | HCID 18443528 | — |
Reaction Steps
A mixture solution of 3-(2-Chloro-4-hydroxy-phenyl)-2-methoxy-propionic acid ethyl ester from Step F and 3-(Biphenyl-4-yloxy)-propan-1-ol were allowed to react under the Standard Mitsounobu coupling conditions B (DIAD/toluene) to give the corresponding coupled product which by the Standard hydrolysis procedure C (NaOH) yield the title compound. MS (ES) for C25H25ClO5 [M+NH4]+: 458.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-6531f292ba034753ac12b305bfa84436 |
| Source note | uspto-grants-2007_03 |