HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-[2-Chloro-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(4-Phenoxyphenoxy)-propan-1-ol | HCID 10243540 | — |
| Reactant | 3-(2-Chloro-4-hydroxy-phenyl)-2-methoxy-propionic acid ethyl ester | HCID 58823024 | — |
| Reactant | HCID 178459888 | HCID 178459888 | — |
| Product | 3-[2-Chloro-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid | HCID 18443586 | — |
Reaction Steps
A mixture solution of 3-(2-Chloro-4-hydroxy-phenyl)-2-methoxy-propionic acid ethyl ester from Example 191, Step F and 3-(4-phenoxy-phenoxy)-propan-1-ol were allowed to react under the Standard Mitsounobu coupling conditions B (DIAD/toluene) to give the corresponding coupled product which by the Standard hydrolysis procedure C (NaOH) yield the title compound. MS (ES) for C25H25ClO6 [M+NH4]+: 474.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-128da9f4f914476c98a94f2ba77c3854 |
| Source note | uspto-grants-2007_03 |