Sodium Hydroxide → HCID 10295790, compound

HRID 459216Notes

Reaction equation

C([O:3][C:4](=[O:40])[C@@H:5]([O:38][CH3:39])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([O:30][Si](C(C)(C)C)(C)C)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>>[OH:30][C:27]1[CH:28]=[CH:29][C:24]([C:21]2[CH:20]=[CH:19][C:18]([O:17][CH2:16][CH2:15][CH2:14][O:13][C:10]3[CH:11]=[CH:12][C:7]([CH2:6][C@H:5]([O:38][CH3:39])[C:4]([OH:40])=[O:3])=[CH:8][CH:9]=3)=[CH:23][CH:22]=2)=[CH:25][CH:26]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 59015143HCID 59015143, compound

Product 1

HCID 10295790HCID 10295790, compound

Procedure

The title compound was prepared from (2S)-3-(4-{3-[4′-(tert-Butyl-dimethyl-silanyloxy)-biphenyl-4-yloxy]-propoxy}-phenyl)-2-methoxy-propionic acid ethyl ester (Step A) by Standard Hydrolysis procedure C (NaOH). MS (ES) for C25H26O6 [M+Na]+: 445.

Sources & evidence

ORD record: ord-46745edc489e4fd7bb9be5b15607d631
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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