Sodium Hydroxide → HCID 58822915, compound

HRID 459218Notes

Reaction equation

HRID 459218 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[C:32]3[CH:33]=[CH:34][C:35]([OH:37])=[CH:36][C:31]=3[O:30][CH:29]=2)=[CH:24][CH:23]=1.[OH-].[Na+]>>[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[C:32]3[CH:33]=[CH:34][C:35]([O:37][CH2:16][CH2:15][CH2:14][O:13][C:10]4[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=4)=[CH:36][C:31]=3[O:30][CH:29]=2)=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 18443658HCID 18443658, compoundHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58822915HCID 58822915, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 3-(4-Fluoro-phenyl)-benzofuran-6-ol under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C27H25FO6 [M+NH4]+: 482, [M+Na]+: 487, [M+H]+: 464.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-122ac5e3ed164a94a100340807c9b356
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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