HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6,7,8-Tetrahydro-2-naphthol → (2S)-2-Methoxy-3-{4-[3-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-propoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6,7,8-Tetrahydro-2-naphthol | HCID 14305 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester | HCID 58822859 | — |
| Product | (2S)-2-Methoxy-3-{4-[3-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-propoxy]-phenyl}-propionic acid | HCID 10200040 | — |
Reaction Steps
(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 5,6,7,8-Tetrahydro-naphthalen-2-ol under the Standard Procedure J. The compound thus obtained was allowed to react under Standard Hydrolysis Procedure C (NaOH) to give the title compound. MS(ES) for C23H28NO5 [M+Na]+: 407, [M+H]+: 385.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-36c2dcb5e63845a0930e04d038ee2347 |
| Source note | uspto-grants-2007_03 |