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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459223Generated: October 26, 2026

6-Benzoyl-2-naphthol → (2S)-3-{4-[3-(6-Benzoyl-naphthalen-2-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid

https://huagongshe.com/reaction/459223

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Benzoyl-2-naphtholHCID 93271—
Reactant(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 58822859—
Product(2S)-3-{4-[3-(6-Benzoyl-naphthalen-2-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acidHCID 18443519—

Reaction Steps

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with (6-Hydroxy-naphthalen-2-yl)-phenyl-methanone under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C(NaOH) to give the title compound. MS(ES) for C30H28O6 [M+Na]+: 507, [M+H]+: 485.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192982B2
Source datasetuspto-grants-2007_03
ORD IDord-888c2184cb2f4ac79c93e2418acf7586
Source noteuspto-grants-2007_03