Sodium Hydroxide → HCID 58822913, compound

HRID 459225Notes

Reaction equation

HRID 459225 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[CH:21]1[C:33]2[CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]=2[CH:24]=[CH:23][C:22]=1[OH:34].[OH-].[Na+]>>[CH:21]1[C:33]2[CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]=2[CH:24]=[CH:23][C:22]=1[O:34][CH2:16][CH2:15][CH2:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 755472-HydroxyfluoreneHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58822913HCID 58822913, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 9H-Fluoren-2-ol under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C26H26O5 [M+Na]+: 441.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-a279dc2a5ea14f7582094dc8117f942e
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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