Sodium Hydroxide → HCID 58822964, compound

HRID 459230Notes

Reaction equation

HRID 459230 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1.[OH-].[Na+]>>[F:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH2:16][CH2:15][CH2:14][O:13][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=3)=[CH:30][CH:29]=2)=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 3454204-Fluoro-4'-hydroxybiphenylHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58822964HCID 58822964, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 4′-Fluoro-biphenyl-4-ol from Step B under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C25H25FO5 [M+NH4]+: 442, [M+Na]+: 447.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-e0d4c9e738fd4ecd99c087982f8671fe
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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