Sodium Hydroxide → HCID 18443459, compound

HRID 459231Notes

Reaction equation

HRID 459231 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[F:21][C:22]([F:41])([F:40])[C:23]1[CH:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=2)[CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1.[OH-].[Na+]>>[F:21][C:22]([F:40])([F:41])[C:23]1[CH:24]=[C:25]([C:33]2[CH:34]=[CH:35][C:36]([O:39][CH2:16][CH2:15][CH2:14][O:13][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=3)=[CH:37][CH:38]=2)[CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 10470389HCID 10470389, compoundHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 18443459HCID 18443459, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 3′,5′-Bis-trifluoromethyl-biphenyl-4-ol from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C27H24F6O5 [M+Na]+: 565, [M+H]+: 543.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-d44cdd564d7d422b947034f01797a495
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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