Sodium Hydroxide → HCID 58823016, compound

HRID 459235Notes

Reaction equation

HRID 459235 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[O:21]1[C:25]2[CH:26]=[CH:27][C:28]([C:30]3[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=3)=[CH:29][C:24]=2[O:23][CH2:22]1.[OH-].[Na+]>>[O:21]1[C:25]2[CH:26]=[CH:27][C:28]([C:30]3[CH:35]=[CH:34][C:33]([O:36][CH2:16][CH2:15][CH2:14][O:13][C:10]4[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=4)=[CH:32][CH:31]=3)=[CH:29][C:24]=2[O:23][CH2:22]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 11481303HCID 11481303, compoundHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58823016HCID 58823016, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 4-Benzo[1,3]dioxol-5-yl-phenol from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C26H26O7 [M+NH4]+: 468, [M+Na]+: 473.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-700317d676cd474481b8830d3069ddda
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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