HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (2S)-2-Methoxy-3-{4-[3-(4'-trifluoromethoxy-biphenyl-4-yloxy)-propoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(4-Trifluoromethoxyphenyl)phenol | HCID 12008734 | — |
| Reactant | (2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester | HCID 58822859 | — |
| Product | (2S)-2-Methoxy-3-{4-[3-(4'-trifluoromethoxy-biphenyl-4-yloxy)-propoxy]-phenyl}-propionic acid | HCID 58822655 | — |
Reaction Steps
(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 4′-Trifluoromethoxy-biphenyl-4-ol from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C26H25F3O6 [M+NH4]+: 508, [M+Na]+: 513.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-4e088b10a29f42fe809a3b9a41310519 |
| Source note | uspto-grants-2007_03 |