Sodium Hydroxide → HCID 58822793, compound

HRID 459243Notes

Reaction equation

HRID 459243 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.OC1C=CC([C:28]2[C:36]([O:37][CH3:38])=[CH:35][CH:34]=[CH:33][C:29]=2[C:30]([NH2:32])=[O:31])=CC=1.[OH-:39].[Na+]>>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:39][C:7]2[CH:12]=[CH:11][C:10]([NH:32][C:30](=[O:31])[C:29]3[CH:33]=[CH:34][CH:35]=[C:36]([O:37][CH3:38])[CH:28]=3)=[CH:9][CH:8]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 86596246HCID 86596246, compound

Product 1

HCID 58822793HCID 58822793, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with N-(4-Hydroxy-phenyl-3-methoxy-benzamide from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C NaOH) to give the title compound. MS(ES) for C27H29NO7 [M+H]+: 480.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-b0470eabe565411da50e93d1f2186e75
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

Loading…