Sodium Hydroxide → HCID 69421198, compound

HRID 459245Notes

Reaction equation

HRID 459245 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[Cl:21][C:22]1[CH:37]=[CH:36][C:25]([C:26]([NH:28][C:29]2[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=2)=O)=[CH:24][CH:23]=1.[OH-].[Na+]>>[Cl:21][C:22]1[CH:37]=[CH:36][C:25]([CH2:26][NH:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:16][CH2:15][CH2:14][O:13][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=3)=[CH:31][CH:30]=2)=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 8550814-chloro-N-(4-hydroxyphenyl)benzamideHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 69421198HCID 69421198, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 4-chloro-N-(4-hydroxyphenyl)benzamide from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C26H26ClNO6 [M+H]+: 484.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-779297a1071448ba8ab405e1772fd70c
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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