Sodium Hydroxide → HCID 10204150, compound

HRID 459253Notes

Reaction equation

HRID 459253 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[OH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([C:30]2[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=2)=[O:29])=[CH:24][CH:23]=1.[OH-].[Na+]>>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:21][C:22]2[CH:23]=[CH:24][C:25]([C:28](=[O:29])[C:30]3[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=3)=[CH:26][CH:27]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 67258(4-Hydroxyphenyl)(4-methylphenyl)methanoneHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 10204150HCID 10204150, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with (4Hydroxy-phenyl)-p-tolyl-methanone from Srep A under the Standar Procedure J. The compound thus obtained was allowed to react under Standar hydrolysis procedure C (NaOH) to give the title compound. Ms(ES) for C27H28O6 [M+NH4]+: 471 [M+H]+: 449.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-dc491e53aa6541789264cfe427aeb72b
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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