Sodium Hydroxide → HCID 58822961, compound

HRID 459254Notes

Reaction equation

HRID 459254 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[OH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:24][CH:23]=1.[OH-].[Na+]>>[CH3:30][C:29]([CH3:32])([CH3:31])[C:28]([C:25]1[CH:24]=[CH:23][C:22]([O:21][CH2:16][CH2:15][CH2:14][O:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=2)=[CH:27][CH:26]=1)=[O:33]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 5780474'-Hydroxy-2,2-dimethylpropiophenoneHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58822961HCID 58822961, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 1-(4-Hydroxyphenyl)-2,2-dimethyl-propan-1-one from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C24H30O6 [M+NH4]+: 437 [M+H]+: 415.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-520e05e8abf14a04af93dad568e5011d
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

Loading…