Sodium Hydroxide → (2S)-2-Methoxy-3-(4-{3-[4-(3-phenyl-propionyl)-phenoxy]-propoxy}-phenyl)-propionic acid

反応式

C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[OH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:37])[CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:24][CH:23]=1.[OH-].[Na+]>>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:21][C:22]2[CH:23]=[CH:24][C:25]([C:28](=[O:37])[CH2:29][CH2:30][C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[CH:26][CH:27]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]

参加物

反応物 3

HCID 14798Sodium Hydroxide

HCID 144161631-(4-Hydroxyphenyl)-3-phenylpropan-1-one

HCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

生成物 1

HCID 10204975(2S)-2-Methoxy-3-(4-{3-[4-(3-phenyl-propionyl)-phenoxy]-propoxy}-phenyl)-propionic acid

実験手順

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with 1-(4-Hydroxy-phenyl)-3-phenyl-propan-1-one from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C28H30O6 [M+NH4]+: 485 [M+H]+: 463.

後処理

customThe compound thus obtained

出典と根拠

ORDレコード: ord-c7bb5812cc4748d6a8e2dd908bf45f85
出典データセット: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07192982B2

反応ノート

読み込み中…