HCID 10114684, compound → HCID 58822995, compound

HRID 459275Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:18])[C@@H:5]([O:15][CH2:16][CH3:17])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([Cl:14])[CH:8]=1)[CH3:2].[C:19]([C:27]1[CH:51]=[CH:50][C:30]([O:31][CH2:32][CH2:33][CH2:34]OC2C=CC(C[C@H](OCC)C(O)=O)=CC=2)=[CH:29][CH:28]=1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:1]([O:3][C:4](=[O:18])[C@@H:5]([O:15][CH2:16][CH3:17])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:34][CH2:33][CH2:32][O:31][C:30]2[CH:50]=[CH:51][C:27]([C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:28][CH:29]=2)=[C:9]([Cl:14])[CH:8]=1)[CH3:2]

Participants

Reactant 2

HCID 10114684HCID 10114684, compound

HCID 58823046HCID 58823046, compound

Product 1

HCID 58822995HCID 58822995, compound

Procedure

The title compound was prepared from (S)-2-ethoxy-3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester and [4-(3-bromo-propoxy)-phenyl]-phenyl-methanone (Example 256) using the Standard Procedure I. The product was purified by column chromatography on silica gel using a 4/1 Hexane/Ethyl acetate mixture as eluent to give the title product. MS(ES) for C29H31ClO6 [M+H]+: 511.1

Workup

customThe product was purified by column chromatography on silica gel using a 4/1 Hexane/Ethyl acetate mixture as eluent

Sources & evidence

ORD record: ord-18ffd20f6c0a4b20a836edb0025a0d0d
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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