4-Chlorobenzaldehyde → N-(4-Chlorobenzyl)-3H-benzo[d]imidazol-5-amine

Participants

Role	Name	HCID	Charge
Reactant	4-Chlorobenzaldehyde	HCID 7726	—
Reactant	5-Aminobenzimidazole	HCID 13623	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Sodium borohydride	HCID 4311764	—
Product	N-(4-Chlorobenzyl)-3H-benzo[d]imidazol-5-amine	HCID 67444221	—

Reaction Steps

Alternatively the compound was synthesized starting from benzimidazol-5-amine (2.66 g; 20 mmol; 1 eq.), 4-chlorobenzaldehyde (3.09 g; 22 mmol; 1.1 eq.), NaBH4 (1.14 g; 30 mmol; 1.5 eq.) and 5 N NaOH (20 ml; 100 mmol; 5 eq.) according to method 2; Yield: 3.94 g (76.7%); MS m/z: 258.3/260.3 [M+H]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541596B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-cefdeab8e05a489a85e32512c71a144a
Source note	uspto-grants-2013_09