4-(2,2,3,3-Tetrafluoropropoxy)phenol → (2S)-2-Methoxy-3-(4-{3-[4-(2,2,3,3-tetrafluoro-propoxy)-phenoxy]-propoxy}-phenyl)-propionic acid ethyl ester

Participants

Reaction Steps

3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 173, Step A) and 4-(2,2,3,3-tetrafluoro-propoxy)-phenol (Step B) were treated under ester K to afford the title compound 1H-NMR (CDCl3, 200.15 MHz): δ 7.13 (d, 2H, J=8.6), 6.85–6.80 (m, 6H), 6.05 (dt, 1H, J=53.2, 5.1), 4.22–4.08 (m, 8H), 3.90 (dd, 1H, J=7.0, 5.6), 3.35 (s, 3H), 3.04–2.86 (m, 2H), 2.22 (qn, 2H, J=6.2).

Provenance & Evidence