Sodium Hydroxide → (2S)-2-Methoxy-3-(4-{3-[4-(2,2,3,3-tetrafluoro-propoxy)-phenoxy]-propoxy}-phenyl)-propionic acid

Participants

Reaction Steps

The title compound was prepared from (2S)-2-methoxy-3-(4-{3-[4-(2,2,3,3-tetrafluoro-propoxy)-phenoxy]-propoxy}-phenyl)-propionic acid ethyl ester (Step C) by standard hydrolysis procedure C (NaOH). 1H-NMR (CDCl3, 200.15 MHz): δ 7.14 (d, 2H, J=8.6), 6.84–6.79 (m, 6H), 6.04 (tt, 1H, J=53.0, 4.8), 4.27 (t, 2H, J=12.0), 4.09 (t, 4H, J=5.9), 3.97–3.91 (m, 1H), 3.34 (s, 3H), 3.11–2.87 (m, 2H), 2.20 (qn, 2H, J=5.9).

Provenance & Evidence