1-Bromo-2-methylpropane → HCID 58822821, compound

Participants

Reaction Steps

(2S)-3-{4-[3-(4-Hydroxy-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester (Example 263, Step B) was coupled under the ester J with 1-bromo-2-methylpropane to afford the title compound. 1H-NMR (CDCl3, 200.15 MHz): δ 7.14 (d, 2H, J=8.6), 6.86–6.82 (m, 6H), 4.11 (q, 4H, J=6.2), 3.98 (dd, 1H, J=7.3, 4.6), 3.66 (d, 2H, J=6.5), 3.40 (s, 3H), 3.10 (dd, 1H, J=14.5, 4.6), 2.95 (dd, 1H, J=14.5, 7.3), 2.21 (qn, 2H, J=6.2), 2.11–1.98 (m, 1H), 1.01 (d, 6H, J=6.7).

Provenance & Evidence