(Pyridin-4-yl)boronic acid → (2S)-2-Methoxy-3-{4-[3-(4-pyridin-4-yl-phenoxy)-propoxy]-phenyl}-propionic acid

Participants

Reaction Steps

The title compound was prepared from (2S)-3-{4-[3-(4-iodo-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester (Example 270, Step A) and 4-pyridyl boronic acid by following the procedure described for Example 270 (Steps B and C). 1H-NMR (CDCl3, 200.15 MHz): δ 8.67–8.65 (m, 2H), 8.16 (d, 2H, J=6.6), 7.90 (d, 2H, J=8.8), 7.16–7.09 (m, 4H), 6.82 (d, 2H, J=8.8), 4.26 (t, 2H, J=6.2), 4.13 (t, 2H, J=6.2), 3.90 (dd, 1H, J=7.7, 4.8), 2.97 (dd, 1H, J=14.3, 5.1), 2.83 (dd, 1H, J=14.3, 7.7), 2.24 (qn, 2H, J=5.9).

Provenance & Evidence