反应详情

The title compound was prepared from (2S)-3-{4-[3-(4-iodo-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester (Example 270, Step A) and 8-quinoline boronic acid by following the procedure described for Example 270 (Steps B and C). 1H-NMR (MeOD, 300.15 MHz): δ 8.82 (d, 1H, J=2.6), 8.39 (d, 1H, J=8.1), 7.92 (d, 1H, J=7.9), 7.74–7.63 (m, 2H), 7.58–7.51 (m, 3H), 7.18 (d, 2H, J=8.5), 7.08 (d, 2H, J=8.7), 6.88 (d, 2H, J=8.7), 4.28 (t, 2H, J=6.0), 4.20 (t, 2H, J=6.3), 3.90–3.80 (m, 1H), 3.30 (s, 3H), 3.04–2.84 (m, 2H), 2.29 (qn, 2H, J=6.3).