Sodium Hydroxide → HCID 58822708, compound

HRID 459296Notes

Reaction equation

C([O:3][C:4](=[O:32])[C@@H:5]([O:30][CH3:31])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>>[CH3:31][O:30][C@@H:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)[C:4]([OH:32])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 58822912HCID 58822912, compound

Product 1

HCID 58822708HCID 58822708, compound

Procedure

The title compound was prepared from (2S)-2-methoxy-3-{4-[3-(4-piperazin-1-yl-phenoxy)-propoxy]-phenyl}-propionic acid ethyl ester (Step A) by standard hydrolysis procedure C (NaOH). 1H-NMR (MeOD 300.15 MHz): δ 7.18 (d, 2H, J=8.5), 6.89–6.83 (m, 4H), 6.72 (d, 2H, J=9.1), 4.30 (t, 2H, J=6.3), 4.07 (t, 2H, J=6.1), 3.86–3.82 (m, 1H), 3.62–3.59 (m, 4H), 3.36 (s, 3H), 3.07–2.83 (m, 6H), 2.12 (qn, 2H, J=6.3).

Sources & evidence

ORD record: ord-5e0e955a385446b2a90e327da6b60c4d
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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