5,6,7,8-Tetrahydro-2-naphthol → (2S)-2-Methoxy-3-{4-[3-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-propoxy]-phenyl}-propionic acid

Participants

Role	Name	HCID	Charge
Reactant	5,6,7,8-Tetrahydro-2-naphthol	HCID 14305	—
Reactant	(2S)-3-{4-[2-(biphenyl-4-yloxy)-ethoxy]-phenyl}-2-methoxy-propionic acid	HCID 10135109	—
Reactant	(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester	HCID 58822859	—
Product	(2S)-2-Methoxy-3-{4-[3-(5,6,7,8-tetrahydro-naphthalen-2-yloxy)-propoxy]-phenyl}-propionic acid	HCID 10200040	—

Reaction Steps

The title compound was prepared from (2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 284, Step 2) and 5,6,7,8-tetrahydro-naphthalen-2-ol via the same procedure used for the: preparation of (2S)-3-{4-[2-(biphenyl-4-yloxy)-ethoxy]-phenyl}-2-methoxy-propionic acid (Example 283, Step 3), to produce a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07192982B2
Source dataset	uspto-grants-2007_03
ORD ID	ord-02f53a511eb8464c94756e4e09765aa5
Source note	uspto-grants-2007_03