Methyl 3-Hydroxybenzoate → HCID 58822659, compound

HRID 459323Notes

Reaction equation

HRID 459323 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.C[O:22][C:23](=[O:31])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([OH:30])[CH:25]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[C:4]([C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:30][C:26]2[CH:25]=[C:24]([CH:29]=[CH:28][CH:27]=2)[C:23]([OH:31])=[O:22])=[CH:11][CH:12]=1)([OH:3])=[O:20]

Participants

4

Reactant 3

HCID 88068Methyl 3-HydroxybenzoateHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

Product 1

HCID 58822659HCID 58822659, compound

Procedure

The title compound was prepared from (2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 284, Step 2) and 3-hydroxy-benzoic acid methyl ester via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a colorless oil.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-51bf84f5cf86495fa762c49ce162297a
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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