3-Bromo-1-propanol → 3-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester

Participants

Reaction Steps

The title compound was prepared from 3-bromo-propan-1-ol (Example 284, Step 1) and 3-(3-hydroxy-phenyl)-2-methoxy-propionic acid methyl ester (Example 291, Step 4) via the same procedure used for the preparation of (2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 284, Step 2). 1H-NMR (CDCl3, 200.15 MHz): 7.26–7.16 (m, 1H), 6.80 (t, 3H, J=7.3), 4.09 (t, 2H, J=5.9), 3.97 (dd, 1H, J=7.3, 5.4), 3.73 (s, 3H), 3.60 (t, 2H, J=6.4), 3.36 (s, 3H), 3.00 (s, 1H), 2.97 (d, 1H, J=3.2), 2.31 (qn, 2H, J=6.2).

Provenance & Evidence