HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 2-Methoxy-3-[3-(3-phenoxy-propoxy)-phenyl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 3-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester | HCID 58822861 | — |
| Reactant | (2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid | HCID 58822897 | — |
| Product | 2-Methoxy-3-[3-(3-phenoxy-propoxy)-phenyl]-propionic acid | HCID 18443266 | — |
Reaction Steps
The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and phenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C19H22O5 [M+Na]+: 353.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-a47352794c914bc68a249a164f69f1fd |
| Source note | uspto-grants-2007_03 |