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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459349Generated: October 27, 2026

Phenol → 2-Methoxy-3-[3-(3-phenoxy-propoxy)-phenyl]-propionic acid

https://huagongshe.com/reaction/459349

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolHCID 996—
Reactant3-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl esterHCID 58822861—
Reactant(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acidHCID 58822897—
Product2-Methoxy-3-[3-(3-phenoxy-propoxy)-phenyl]-propionic acidHCID 18443266—

Reaction Steps

The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and phenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enantiomers were separated by chiral HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192982B2
Source datasetuspto-grants-2007_03
ORD IDord-2324643d9a654c439e1e72860e43ffd5
Source noteuspto-grants-2007_03