HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-Hydroxybenzoate → 3-{3-[3-(2-Carboxy-2-methoxy-ethyl)-phenoxy]-propoxy}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-Hydroxybenzoate | HCID 88068 | — |
| Reactant | 3-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester | HCID 58822861 | — |
| Reactant | (2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid | HCID 58822897 | — |
| Product | 3-{3-[3-(2-Carboxy-2-methoxy-ethyl)-phenoxy]-propoxy}-benzoic acid | HCID 18443591 | — |
Reaction Steps
The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 3-hydroxybenzoic acid methyl ester via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C20H22O7 [M+Na]+: 397.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-9495912daa7740d78354bc1540551e5c |
| Source note | uspto-grants-2007_03 |