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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459357Generated: October 29, 2026

2-Naphthol → HCID 18443265, compound

https://huagongshe.com/reaction/459357

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-NaphtholHCID 8663—
Reactant3-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl esterHCID 58822861—
Reactant(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acidHCID 58822897—
ProductHCID 18443265HCID 18443265—

Reaction Steps

The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 2-naphthol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192982B2
Source datasetuspto-grants-2007_03
ORD IDord-8e9dcad6ff4246dbad97b444e8e041d2
Source noteuspto-grants-2007_03