HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylic Acid → 2-{3-[3-(2-Carboxy-2-methoxy-ethyl)-phenoxy]-propoxy}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylic Acid | HCID 338 | — |
| Reactant | 3-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester | HCID 58822861 | — |
| Reactant | (2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid | HCID 58822897 | — |
| Product | 2-{3-[3-(2-Carboxy-2-methoxy-ethyl)-phenoxy]-propoxy}-benzoic acid | HCID 18443250 | — |
Reaction Steps
The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 2-hydroxy-benzoic acid via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C20H22O7 [M+H]+: 375.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-cc5bb65285f64275a9566a751feb996b |
| Source note | uspto-grants-2007_03 |