Potassium Carbonate → HCID 178505932, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	2,4,5-Trifluorobenzyl Bromide	HCID 2777057	—
반응물	tert-Butyl 5-amino-1H-benzo[d]imidazole-1-carboxylate	HCID 53406968	—
생성물	HCID 178505932	HCID 178505932	—

반응 단계

The compound was synthesized starting from N1-Boc-benzimidazol-5-amine (233 mg; 1 mmol; 1 eq.), 2,4,5-trifluorbenzylbromide (563 mg; 2.5 mmol; 2.5 eq.) and K2CO3 (345 mg; 2.5 mmol; 2.5 eq.) according to method 4; Yield: 0.172 (40.9%); MS m/z: 422.2 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 4.68 (s, 4H); 6.74 (dd, 1H, 4J=2.1 Hz, 3J=8.9 Hz); 6.78 (br s, 1H); 7.23-7.29 (m, 2H); 7.39 (d, 1H, 3J=8.9 Hz); 7.51-7.56 (m, 2H); 7.97 (s, 1H); 12.03 (br s, 1H); HPLC (METHOD [A]): rt 16.46 min (100%)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08541596B2
출처 데이터셋	uspto-grants-2013_09
ORD ID	ord-ecb8a92aeb5545a48da92a2f29f51cb2
출처 메모	uspto-grants-2013_09