HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isopropylphenol → 3-{3-[2-(2-Isopropyl-phenoxy)-ethoxy]-phenyl}-2-methoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isopropylphenol | HCID 6943 | — |
| Reactant | (2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid | HCID 58822897 | — |
| Reactant | 3-[3-(2-Bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester | HCID 69423413 | — |
| Product | 3-{3-[2-(2-Isopropyl-phenoxy)-ethoxy]-phenyl}-2-methoxy-propionic acid | HCID 18443588 | — |
Reaction Steps
The title compound was prepared from 2-isopropyl-phenol and 3-[3-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 351, Step 1) via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C21H26O5 [M−H]−:357.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-2d0d014cfab341ee881f6deb4c05aae6 |
| Source note | uspto-grants-2007_03 |