HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyphenol → 2-Methoxy-3-{3-[2-(3-methoxy-phenoxy)-ethoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | (2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid | HCID 58822897 | — |
| Reactant | 3-[3-(2-Bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester | HCID 69423413 | — |
| Product | 2-Methoxy-3-{3-[2-(3-methoxy-phenoxy)-ethoxy]-phenyl}-propionic acid | HCID 18443259 | — |
Reaction Steps
The title compound was prepared from 3-methoxy-phenol and 3-[3-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 351, Step 1) via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C19H22O6 [M−H]−: 345.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-ee40c24ecf554bc29086cf5f74cb6c05 |
| Source note | uspto-grants-2007_03 |