2-Hydroxyfluorene → HCID 58822901, compound

HRID 459382Notes

Reaction equation

HRID 459382 reaction equation
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[CH:20]1[C:32]2[CH2:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]=2[CH:23]=[CH:22][C:21]=1[OH:33].CO[C@@H](CC1C=CC=CC=1OCCCOC1C=CC=CC=1)C(O)=O>>[CH:20]1[C:32]2[CH2:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]=2[CH:23]=[CH:22][C:21]=1[O:33][CH2:15][CH2:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:17][CH3:18])[C:4]([OH:3])=[O:19])=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 755472-HydroxyfluoreneHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl esterHCID 69425144HCID 69425144, compound

Product 1

HCID 58822901HCID 58822901, compound

Procedure

The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and 9H-fluoren-2-ol via the same procedure used for the preparation of (2S)-2-methoxy-3-[(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a white solid. MS (ES) for C25H24O5 [M+Na]+: 427.3.

Workup

  1. customto produce a white solid

Sources & evidence

ORD record
ord-346d90595ebc4d3396f9631ea7133e4e
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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